If your Hotas One flight stick is not connecting to Microsoft Flight Simulator, there are a few troubleshooting steps you can try. First, make sure that your stick is properly connected to your computer and that the drivers are up to date. Then, check your game settings to ensure that the Hotas controller is enabled. If the issue persists, try uninstalling and reinstalling the game and/or the controller drivers. If you are still having trouble, you may need to contact Microsoft Support for further assistance.