While there is no single medicine that is best for gastric problems, simethicone (Gas-X, Mylanta Gas Minis, others) [1] can help break up the bubbles in gas and may help gas pass through your digestive tract. Other medications, such as those containing alpha-galactosidase [2], aluminum hydroxide, magnesium hydroxide, and simethicone systemic [3], may also help relieve gas. Your doctor can help you determine which medication is best for your particular gastric problem after conducting a medical history review, dietary habits review, physical exam, and other diagnostic tests.